Brain Mechanisms of Neurodevelopmental Disorders

 Shenfeng Qiu Laboratory

The Qiu laboratory is dedicated to the understanding of the origins of neurodevelopmental and neuropsychiatric disorders, in which genetic components play a critical role in the disease pathogenesis.  Currently, most efforts focus on autism spectrum disorders. We are also interested in neurocircuit mechanisms and brain maladaptive changes underlying neuropsychiatric conditions, such as schizophrenia and major depression.

Our work leverages the power of
genetic mouse models, coupled with basic neurobiology, neuroanatomy, electrophysiology, and behavior to obtain a system-level understanding of disease mechanisms. Ultimately, these novel mechanisms will guide cell-type and circuit-specific therapeutics of neurodevelopmental disorders.

 

Additional research videos on Youtube:

In vivo
16 channel single unit recordings in mouse prefrontal cortex (wide band)
In vivo 16 channel single unit recordings in behaving mice (
SPKC data)(new!)
Imaris reconstruction of a
mouse brain 3-D volume
Single unit recording on mouse V1 binocular zone (
Ocular Dominance plasticity)
Receptor field testing of V1 neurons
Microglia motility in mouse visual cortex (over 30 min)